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Mol Biol Evol. 2015 Dec;32(12):3186-93. doi: 10.1093/molbev/msv187. Epub 2015 Sep 3.

Distribution of Ribonucleoprotein and Protein-Only RNase P in Eukarya.

Author information

1
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany.
2
Zentrum für Anatomie & Zellbiologie, Medizinische Universität Wien, Wien, Austria.
3
Institut de Biologie Moléculaire des Plantes du CNRS, Strasbourg, France.
4
Institut de Biologie Moléculaire des Plantes du CNRS, Strasbourg, France anthony.gobert@ibmp-cnrs.unistra.fr giege@unistra.fr.

Abstract

RNase P is the endonuclease that removes 5' leader sequences from tRNA precursors. In Eukarya, separate RNase P activities exist in the nucleus and mitochondria/plastids. Although all RNase P enzymes catalyze the same reaction, the different architectures found in Eukarya range from ribonucleoprotein (RNP) enzymes with a catalytic RNA and up to 10 protein subunits to single-subunit protein-only RNase P (PRORP) enzymes. Here, analysis of the phylogenetic distribution of RNP and PRORP enzymes in Eukarya revealed 1) a wealth of novel P RNAs in previously unexplored phylogenetic branches and 2) that PRORP enzymes are more widespread than previously appreciated, found in four of the five eukaryal supergroups, in the nuclei and/or organelles. Intriguingly, the occurrence of RNP RNase P and PRORP seems mutually exclusive in genetic compartments of modern Eukarya. Our comparative analysis provides a global picture of the evolution and diversification of RNase P throughout Eukarya.

KEYWORDS:

PRORP; RNase P; eukaryal evolution; ribonucleoproteins; tRNA biogenesis

PMID:
26341299
DOI:
10.1093/molbev/msv187
[Indexed for MEDLINE]

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