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Folia Morphol (Warsz). 2015;74(3):325-34. doi: 10.5603/FM.2015.0049.

Ameliorative potentials of a combination of fenugreek and alpha-tocopherol on cadmium induced testicular toxicity: an ultrastructural study.

Author information

1
Anatomy Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.. hesham977@hotmail.com.

Abstract

BACKGROUND:

The current study aimed to elucidate the protective role of combined fenugreek and a-tocopherol against cadmium induced histopathological changes in the testes.

MATERIALS AND METHODS:

Thirty adult male albino rats divided into three equal groups 10 rats each. Group I is the control group. Group II received 5 mg/kg/ day cadmium chloride. Group III received 5 mg/kg/day cadmium chloride and 150 mg/kg/day fenugreek and 100 mg/kg/day of a-tocopherol. The treatment of all groups was done by oral gavage for 60 consecutive days. The testes were removed and subjected to histopathological and ultrastructure study.

RESULTS:

Rats exposed to cadmium showed severe histopathological changes in the testicular spermatogenic series, many vacuoles and multinucleated giant cells. Treatment with fenugreek and a-tocopherol partially improved the morphological changes, reduced tissue damage and rebuilt of the spermatogonia layer.

CONCLUSIONS:

Fenugreek and a-tocopherol might represent a promising medicinal combination to ameliorate the toxic effects of cadmium exposure.

KEYWORDS:

a-tocopherol; cadmium chloride; fenugreek; seminiferous epithelium; ultrastructure

PMID:
26339813
DOI:
10.5603/FM.2015.0049

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