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Mediators Inflamm. 2015;2015:952536. doi: 10.1155/2015/952536. Epub 2015 Aug 3.

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.

Author information

1
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary.
2
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary ; MTA-SE "Lendület" Experimental and Translational Immunomics Research Group, 4 Nagyvárad Square, Budapest 1089, Hungary.
3
Department of Genetics, Cell- and Immunobiology, Semmelweis University, 4 Nagyvárad Square, Budapest 1089, Hungary ; Department of Rheumatology, Faculty of Medicine, Semmelweis University, 4 Frankel Leó Street, Budapest 1023, Hungary.

Abstract

Although Src-like adaptor proteins (SLAP-1 and SLAP-2) were mainly studied in lymphocytes, where they act as negative regulators and provide fine control of receptor signaling, recently, several other functions of these proteins were discovered. In addition to the well-characterized immunoregulatory functions, SLAP proteins appear to have an essential role in the pathogenesis of type I hypersensitivity, osteoporosis, and numerous malignant diseases. Both adaptor proteins are expressed in a wide variety of tissues, where they have mostly inhibitory effects on multiple intracellular signaling pathways. In this review, we summarize the diverse effects of SLAP proteins.

PMID:
26339145
PMCID:
PMC4539169
DOI:
10.1155/2015/952536
[Indexed for MEDLINE]
Free PMC Article

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