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Aust N Z J Psychiatry. 2016 Mar;50(3):228-42. doi: 10.1177/0004867415603131. Epub 2015 Sep 2.

Coffee and caffeine consumption and depression: A meta-analysis of observational studies.

Author information

1
Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.
2
Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China zhangdf1961@126.com zhangdf1962@aliyun.com.

Abstract

OBJECTIVE:

The results from observation studies on the relationship between coffee intake and risk of depression and the relationship between caffeine consumption and depression remain controversial. We conducted a meta-analysis with a dose-response analysis to quantitatively summarize the evidence about the association between coffee and caffeine intakes and risk of depression.

METHOD:

Relevant articles were identified by researching PubMed, Web of Science, China National Knowledge Infrastructure and WANFANG DATA in English or Chinese from 1 January 1980 to 1 May 2015. Case-control, cohort or cross-sectional studies evaluating coffee or caffeine consumption and depression were included. A random-effects model was used to combine study-specific relative risk and 95% confidence interval. Dose-response relationship was assessed by restricted cubic spline functions.

RESULTS:

Data were obtained from 11 observation articles; 330,677 participants from seven studies in seven articles were included in the coffee-depression analysis, while 38,223 participants from eight studies in seven articles were involved in the caffeine-depression analysis. Compared with the lowest level consumption, the pooled relative risk (95% confidence interval) for coffee-depression and caffeine-depression was 0.757 [0.624, 0.917] and 0.721 [0.522, 0.997], respectively. For dose-response analysis, evidence of a linear association was found between coffee consumption and depression, and the risk of depression decreased by 8% (relative risk = 0.92, 95% confidence interval = [0.87, 0.97], p = 0.002) for each cup/day increment in coffee intake; a nonlinear association was found between caffeine consumption and depression, the risk of depression decreased faster and the association became significant when the caffeine consumption was above 68 mg/day and below 509 mg/day.

CONCLUSIONS:

Coffee and caffeine consumption were significantly associated with decreased risk of depression.

KEYWORDS:

Coffee; caffeine; depression; dose–response analysis and meta-analysis

PMID:
26339067
DOI:
10.1177/0004867415603131
[Indexed for MEDLINE]

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