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Science. 2015 Sep 4;349(6252):aaa4352. doi: 10.1126/science.aaa4352.

Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.

Author information

1
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
2
Department of Pharmacology, Northwestern University, Chicago, IL, USA.
3
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA. minsoo_kim@urmc.rochester.edu.

Abstract

During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.

PMID:
26339033
PMCID:
PMC4809646
DOI:
10.1126/science.aaa4352
[Indexed for MEDLINE]
Free PMC Article

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