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Neonatology. 2015;108(4):253-8. doi: 10.1159/000437347. Epub 2015 Aug 25.

Transitional Changes in Cerebral Blood Volume at Birth.

Author information

1
Research Unit for Cerebral Development and Oximetry, Medical University of Graz, Graz, Austria.

Abstract

BACKGROUND:

Near-infrared spectroscopy (NIRS) enables non-invasive measurements of changes in the concentration of oxygenated (x0394;HbO2) and reduced (x0394;HbR) haemoglobin. Changes in total haemoglobin (x0394;HbT = x0394;HbO2 + x0394;HbR) provide information on changes in cerebral blood volume (CBV).

OBJECTIVE:

The aim was to evaluate the behaviour of CBV during immediate postnatal transition in term infants.

DESIGN:

This observational study was conducted at the Medical University of Graz. NIRS measurements were carried out in term infants without need for respiratory support by using 'NIRO 200-NX' (Hamamatsu) over the first 15 min after birth.

RESULTS:

109 infants with a mean gestational age of 38 + 6 weeks (±7 days) and birth weight of 3,242 g (±481) were included. Related to a reference value at minute 15, a significant decrease of HbT was observed for each minute within the study period. The mean (±SD) decrease of HbT of 17 (±40) µmol/l from minutes 2 to 15 represents a decrease of CBV of 1.0 ml/100 g brain (±2.2).

CONCLUSIONS:

In healthy newborns, CBV decreased over the whole study period. This likely reflects a physiological process. The impact and clinical relevance of different CBV behaviour during immediate transition needs to be investigated in further studies.

PMID:
26338713
DOI:
10.1159/000437347
[Indexed for MEDLINE]

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