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Obes Surg. 2015 Nov;25(11):2225-9. doi: 10.1007/s11695-015-1872-7.

rs4771122 Predicts Multiple Measures of Long-Term Weight Loss After Bariatric Surgery.

Author information

1
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA. ljrtorvik@northwestern.edu.
2
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lakeshore Drive, Suite 1400, Chicago, IL, 60611, USA.
3
Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
4
NorthShore Research Institute, NorthShore University Health System, Evanston, IL, USA.
5
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Abstract

We examined the association of 34 single nucleotide polymorphisms with weight loss up to 9.5 years after Roux-en-Y surgery. Participants were enrollees in the NUgene biobank with stored DNA and linked electronic health records. Ninety-five self-identified white participants underwent surgery and had follow-up weights obtained between 1 and 9.5 years after surgery. SNP rs4771122 was the variant most significantly associated with long-term weight loss after surgery in a repeated linear mixed model (pā€‰=ā€‰.004) of long-term weight loss. In this model, each additional copy of the minor allele was associated with nearly 5 % greater percentage weight loss. This same SNP was also nominally significantly (pā€‰<ā€‰.05) associated with weight loss trajectories, weight loss nadir, and weight loss 2 years after surgery.

KEYWORDS:

Bariatric surgery; Long-term weight loss; Obesity GWAS; Predictors; Repeated measures; Roux-en-Y gastric bypass; SNP

PMID:
26337695
PMCID:
PMC4598314
DOI:
10.1007/s11695-015-1872-7
[Indexed for MEDLINE]
Free PMC Article

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