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Curr Environ Health Rep. 2015 Dec;2(4):379-87. doi: 10.1007/s40572-015-0066-8.

The Impact of Bisphenol A and Phthalates on Allergy, Asthma, and Immune Function: a Review of Latest Findings.

Author information

1
Department of Medicine, Columbia University Medical Center, MH 6C-12, New York, NY, 10032, USA. lbr2129@cumc.columbia.edu.
2
Department of Medicine, Columbia University Medical Center, MH 6C-12, New York, NY, 10032, USA. rlm14@cumc.columbia.edu.
3
Department of Pediatrics, Columbia University Medical Center, New York, NY, USA. rlm14@cumc.columbia.edu.
4
Department of Environmental Health Sciences, Columbia University Medical Center, New York, NY, USA. rlm14@cumc.columbia.edu.
5
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University Medical Center, PH8E-101B, New York, NY, 10032, USA. rlm14@cumc.columbia.edu.

Abstract

In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine-disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, is ubiquitous. The links between their exposure and the development of allergy, asthma, and immune dysfunction have been studied in vitro, in vivo, and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy, and asthma after dietary and inhalation exposure to these chemicals, may be occurring.

KEYWORDS:

Allergy; Asthma; Bisphenol A; Immunotoxicity; Phthalates; Wheeze

PMID:
26337065
PMCID:
PMC4626318
DOI:
10.1007/s40572-015-0066-8
[Indexed for MEDLINE]
Free PMC Article

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