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Curr Opin Microbiol. 2015 Oct;27:86-95. doi: 10.1016/j.mib.2015.07.012. Epub 2015 Sep 1.

High-throughput bacterial functional genomics in the sequencing era.

Author information

1
Department of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA.
2
Graduate Group in Biophysics, University of California, San Francisco, CA 94158, USA.
3
Department of Microbiology and Immunology, University of California, San Francisco, CA 94158, USA; Department of Cell and Tissue Biology, University of California, San Francisco, CA 94158, USA. Electronic address: cgrossucsf@gmail.com.

Abstract

High-throughput functional genomic technologies are accelerating progress in understanding the diversity of bacterial life and in developing a systems-level understanding of model bacterial organisms. Here we highlight progress in deep-sequencing-based functional genomics, show how whole genome sequencing is enabling phenotyping in organisms recalcitrant to genetic approaches, recount the rapid proliferation of functional genomic approaches to non-growth phenotypes, and discuss how advances are enabling genome-scale resource libraries for many different bacteria.

PMID:
26336012
PMCID:
PMC4659725
DOI:
10.1016/j.mib.2015.07.012
[Indexed for MEDLINE]
Free PMC Article

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