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Neuron. 2015 Sep 2;87(5):1106-18. doi: 10.1016/j.neuron.2015.08.018.

Contrasting Roles for Orbitofrontal Cortex and Amygdala in Credit Assignment and Learning in Macaques.

Author information

1
Department of Experimental Psychology, University of Oxford, OX1 3UD, Oxford, UK; Department of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong. Electronic address: boltonchau@gmail.com.
2
Department of Experimental Psychology, University of Oxford, OX1 3UD, Oxford, UK.
3
Department of Experimental Psychology, University of Oxford, OX1 3UD, Oxford, UK; MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK.

Abstract

Recent studies have challenged the view that orbitofrontal cortex (OFC) and amygdala mediate flexible reward-guided behavior. We trained macaques to perform an object discrimination reversal task during fMRI sessions and identified a lateral OFC (lOFC) region in which activity predicted adaptive win-stay/lose-shift behavior. Amygdala and lOFC activity was more strongly coupled on lose-shift trials. However, lOFC-amygdala coupling was also modulated by the relevance of reward information in a manner consistent with a role in establishing how credit for reward should be assigned. Day-to-day fluctuations in signals and signal coupling were correlated with day-to-day fluctuation in performance. A second experiment confirmed the existence of signals for adaptive stay/shift behavior in lOFC and reflecting irrelevant reward in the amygdala in a probabilistic learning task. Our data demonstrate that OFC and amygdala each make unique contributions to flexible behavior and credit assignment.

PMID:
26335649
PMCID:
PMC4562909
DOI:
10.1016/j.neuron.2015.08.018
[Indexed for MEDLINE]
Free PMC Article

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