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Cancer Lett. 2015 Dec 1;369(1):45-9. doi: 10.1016/j.canlet.2015.08.025. Epub 2015 Aug 31.

Radon exposure and oropharyngeal cancer risk.

Author information

1
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain.
2
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; CIBER de Epidemiología y Salud Pública, CIBERESP, Spain; Service of Preventive Medicine, University Hospital Complex of Santiago de Compostela, Spain.
3
Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain; CIBER de Epidemiología y Salud Pública, CIBERESP, Spain. Electronic address: alberto.ruano@usc.es.

Abstract

Oropharyngeal cancer is a multifactorial disease. Alcohol and tobacco are the main risk factors. Radon is a human carcinogen linked to lung cancer risk, but its influence in other cancers is not well known. We aim to assess the effect of radon exposure on the risk of oral and pharyngeal cancer through a systematic review of the scientific literature. This review performs a qualitative analysis of the available studies. 13 cohort studies were included, most of them mortality studies, which analysed the relationship between occupational or residential radon exposure with oropharyngeal cancer mortality or incidence. Most of the included studies found no association between radon exposure and oral and pharyngeal cancer. This lack of effect was observed in miners studies and in general population studies. Further research is necessary to quantify if this association really exists and its magnitude, specially performing studies in general population, preferably living in areas with high radon levels.

KEYWORDS:

Oropharyngeal neoplasms; Radon; Systematic review

PMID:
26335172
DOI:
10.1016/j.canlet.2015.08.025
[Indexed for MEDLINE]

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