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J Med Virol. 2016 Apr;88(4):719-23. doi: 10.1002/jmv.24373. Epub 2015 Sep 21.

Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes.

Author information

1
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia.
2
Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee.
3
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas.
4
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
5
Group Health Research Institute, Seattle Washington.
6
Marshfield Clinic Research Foundation, Marshfield Wisconsin.
7
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
8
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania.
9
Scott and White Healthcare, Temple, Texas.

Abstract

We evaluated the cycle threshold (CT) values of 1,160 influenza A positive and 806 influenza B positive specimens from two seasons of the US Flu VE Network to identify factors associated with CT values. Low CT values (high genomic load) were associated with shorter intervals between illness onset and specimen collection, young age (ages 3-8 years old), and self-rated illness severity for both influenza A and B. Low CT values were also associated with reported fever/feverishness and age ≥65 years for influenza A.

KEYWORDS:

Influenza; RT-PCR; cycle threshold value

PMID:
26334765
DOI:
10.1002/jmv.24373
[Indexed for MEDLINE]

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