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J Dig Dis. 2015 Nov;16(11):634-41. doi: 10.1111/1751-2980.12286.

Is gallstone disease associated with inflammatory bowel diseases? A meta-analysis.

Author information

1
Department of Gastroenterology, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Abstract

OBJECTIVE:

To investigate the association between inflammatory bowel disease (IBD) and gallstone disease (GD) by performing a meta-analysis.

METHODS:

PubMed, Medline, Embase, Web of Science and the Cochrane Library were searched for relevant articles published between January 1980 and February 2015. All statistical analyses were performed using STATA 12.0. A fixed-effects model was adopted; heterogeneity was evaluated by χ(2) test and I(2) statistic; publication bias was assessed by Begg's and Egger's tests.

RESULTS:

Five studies qualified for inclusion in the meta-analysis. Patients with IBD had a significantly higher prevalence of GD than those in the control group [odds ratio (OR) 1.72, 95% confidence interval (CI) 1.40-2.12, P < 0.0001]. Subgroup analyses showed a significantly higher prevalence of GD in patients with Crohn's disease (CD) (OR 2.05, 95% CI 1.61-2.63, P < 0.0001). However, no significant difference in the prevalence of GD was observed between patients with ulcerative colitis (UC) and controls (OR 1.12, 95% CI 0.75-1.68, P = 0.585). Studies from Italy, Sweden and the UK revealed a higher prevalence of GD in patients with IBD. No heterogeneity (I(2) = 25.2%, P = 0.228) or publication bias was observed in our meta-analysis (Begg's test, P = 0.711; Egger's test, P = 0.805).

CONCLUSIONS:

Our meta-analysis suggests there is a trend towards higher prevalence of GD in IBD patients, and especially in patients with CD. More rigorous, large-scale multi-center studies are required to investigate the association between GD and IBD.

KEYWORDS:

Crohn disease; gallstones; inflammatory bowel disease; meta-analysis; ulcerative colitis

PMID:
26332254
DOI:
10.1111/1751-2980.12286
[Indexed for MEDLINE]

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