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Dev Med Child Neurol. 2016 Jan;58(1):85-92. doi: 10.1111/dmcn.12865. Epub 2015 Aug 28.

Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003.

Author information

1
UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525, Grenoble, France.
2
CHU Grenoble, Pôle Santé Publique, Grenoble, France.
3
Norwich Medical School, University of East Anglia, Norwich, UK.
4
The Cerebral Palsy Register of Norway, Vestfold Hospital Trust, Tønsberg, Norway.
5
University Children's Hospital, Department of Paediatric Neurology, Tuebingen, Germany.
6
IMAS12 Research Institute, CIBERESP, Madrid, Spain.
7
RHEOP, Grenoble, France.

Abstract

AIM:

To monitor the trends in prevalence of cerebral palsy (CP) by birthweight in Europe, 1980 to 2003.

METHOD:

Data were collated from 20 population-based registers contributing to the Surveillance of Cerebral Palsy in Europe database. Trend analyses were conducted in four birthweight groups: <1000g (extremely low birthweight [ELBW]); 1000 to 1499g (very low birthweight [VLBW]); 1500 to 2499g (moderately low birthweight [MLBW]); and >2499g (normal birthweight [NBW]).

RESULTS:

The overall prevalence of CP decreased from 1.90 to 1.77 per 1000 live births, p<0.001, with a mean annual fall of 0.7% (95% confidence interval [CI] -0.3% to -1.0%). Prevalence in NBW children showed a non-significant trend from 1.17 to 0.89 per 1000 live births (p=0.22). Prevalence in MLBW children decreased from 8.5 to 6.2 per 1000 live births (p<0.001), but not linearly. Prevalence in VLBW children also declined from 70.9 to 35.9 per 1000 live births (p<0.001) with a mean annual fall of 3.4% (95% CI -2.4% to -4.3%). Prevalence in ELBW children remained stable, at a mean rate of 42.4 per 1000 live births.

INTERPRETATION:

The decline in prevalence of CP in children of VLBW continues, and confirms that previously reported. For the first time, there is also a significant decline among those of MLBW, resulting in a significant overall decrease in the prevalence of CP.

PMID:
26330098
DOI:
10.1111/dmcn.12865
[Indexed for MEDLINE]
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