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Crit Care. 2015 Sep 1;19:307. doi: 10.1186/s13054-015-1034-2.

Oxygen--a limiting factor for brain recovery.

Hadanny A1,2, Efrati S3,4,5,6.

Author information

1
Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, 70300, Israel.
2
Sackler School of Medicine, Tel-Aviv University, Klachkin 25, Tel Aviv, 69978, Israel.
3
Sagol Center for Hyperbaric Medicine and Research, Assaf Harofeh Medical Center, Zerifin, 70300, Israel. efratishai@013.net.
4
Sackler School of Medicine, Tel-Aviv University, Klachkin 25, Tel Aviv, 69978, Israel. efratishai@013.net.
5
Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, 70300, Israel. efratishai@013.net.
6
Sagol School of Neuroscience, Tel-Aviv University, Klachkin 25, Tel Aviv, 69978, Israel. efratishai@013.net.

Abstract

Effective brain metabolism is highly dependent on a narrow therapeutic window of oxygen. In major insults to the brain (e.g., intracerebral hemorrhage), a slight decrease in oxygen supply, as occurs in a hypobaric environment at high altitude, has devastating effects on the injured brain tissue. Conversely, increasing brain oxygenation, by the use of hyperbaric oxygen therapy, can improve brain metabolism and its dependent regenerative processes.

PMID:
26329929
PMCID:
PMC4556415
DOI:
10.1186/s13054-015-1034-2
[Indexed for MEDLINE]
Free PMC Article

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