Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Nutr. 2016 Sep;55(6):2117-27. doi: 10.1007/s00394-015-1026-7. Epub 2015 Sep 2.

Protein intake in early childhood and cardiometabolic health at school age: the Generation R Study.

Author information

1
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. trudy.voortman@erasmusmc.nl.
2
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. trudy.voortman@erasmusmc.nl.
3
Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
4
The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
5
Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

Abstract

PURPOSE:

High protein intake in infancy has been linked to obesity. We aimed to examine the associations of protein intake in early childhood with cardiovascular and metabolic outcomes at school age.

METHODS:

This study was performed in 2965 children participating in a population-based prospective cohort study. Protein intake at 1 year was assessed with a food frequency questionnaire and was adjusted for energy intake. At the children's age of 6 years, we measured their body fat percentage (BF%), blood pressure (BP), and insulin, HDL cholesterol, and triglyceride serum levels. These measures were incorporated into a cardiometabolic risk factor score, using age- and sex-specific SD scores.

RESULTS:

In covariate-adjusted models, higher protein intake was associated with a higher BF%, lower diastolic BP, and lower triglyceride levels. We observed a significant interaction of protein intake with child sex on metabolic outcomes. Stratified analyses showed that protein intake was positively associated with BF% [0.07 SD (95 % CI 0.02; 0.13) per 10 g/day] and insulin levels in girls, but not in boys. In boys, but not in girls, higher protein intake was associated with lower triglyceride levels [-0.12 SD (95 % CI -0.20; -0.04) per 10 g/day] and a lower cardiometabolic risk factor score. Protein intake was not consistently associated with systolic BP or HDL cholesterol levels.

CONCLUSION:

Protein intake in early childhood was associated with a higher BF% and higher insulin levels at 6 years in girls and with lower triglyceride levels in boys. Further studies are needed to explore these sex differences and to investigate whether the observed changes persist into adulthood.

KEYWORDS:

Blood pressure; Body fat; Children; Dietary protein; Epidemiology; Insulin

PMID:
26329684
PMCID:
PMC5009172
DOI:
10.1007/s00394-015-1026-7
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center