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Biomarkers. 2015;20(5):328-37. doi: 10.3109/1354750X.2015.1068867. Epub 2015 Jul 31.

Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic.

Author information

1
a AXO Science SAS , Lyon , France .

Abstract

CONTEXT:

Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer.

OBJECTIVE:

To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer.

MATERIALS AND METHODS:

Urinary biomarker concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis.

RESULTS:

A five-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set.

DISCUSSION AND CONCLUSION:

This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.

KEYWORDS:

Biomarkers; bladder cancer; invasiveness; recurrence

PMID:
26329530
DOI:
10.3109/1354750X.2015.1068867
[Indexed for MEDLINE]

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