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Sleep Med Clin. 2015 Sep;10(3):207-14, xi. doi: 10.1016/j.jsmc.2015.05.022. Epub 2015 Jul 15.

Restless Leg Syndrome/Willis-Ekbom Disease Pathophysiology.

Author information

1
Department of Neurology, Johns Hopkins University, Asthma & Allergy Building, 1B76b, 5501 Hopkins Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address: rallen6@jhmi.edu.

Abstract

Restless leg syndrome/Willis-Ekbom disease has brain iron deficiency that produces excessive dopamine and known genetic risks, some of which contribute to the brain iron deficiency. Dopamine treatments work temporarily but may eventually produce further postsynaptic down-regulation and worse restless leg syndrome. This article includes sections focused on pathophysiologic findings from each of these areas: genetics, cortical-spinal excitability, and iron and dopamine.

KEYWORDS:

Dopamine; Iron; PLMS; RLS augmentation; RLS/WED

PMID:
26329430
PMCID:
PMC4559751
DOI:
10.1016/j.jsmc.2015.05.022
[Indexed for MEDLINE]
Free PMC Article

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