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Ren Fail. 2015 Jul;37(6):929-34. doi: 10.3109/0886022X.2015.1052979. Epub 2015 Sep 2.

Vitamin D deficiency and the risk of anemia: a meta-analysis of observational studies.

Author information

1
a Department of Esophagus, Mediastinal Oncosurgery , Cancer Center of Guangzhou Medical University , Guangzhou , China .
2
b Department of Pediatrics , Guangzhou Women and Children's Medical Center, Guangzhou Medical University , Guangzhou , China .
3
c Department of Urology , the first affiliated Hospital of Guangzhou Medical University , Guangzhou , China , and.
4
d Department of Cardiac Surgery , Guangdong General Hospital of Armed Police , Guangzhou , China.

Abstract

AIMS:

Anemia and vitamin D deficiency (VDD) are both very important health issues, recent accumulating evidence shows that VDD is prevalent in individuals with anemia. This meta-analysis aimed to detect a relationship between VDD and anemia.

METHODS:

We identified eligible studies by searching the Pub Med, Embase and Cochrane Library before October 2014. Quality assessments were performed with the Newcastle-Ottawa Scale. Heterogeneity was evaluated by Cochran's Q test and source of heterogeneity was detected by subgroup analysis and sensitivity analysis.

RESULTS:

A total of seven studies involving 5183 participants were included in the meta-analysis. VDD was associated with an increased incidence of anemia (OR = 2.25, 95% CI = 1.47-3.44), with significant evidence of heterogeneity among these studies (p for heterogeneity < 0.001, I(2)‚ÄČ= 84.0%). The subgroup and sensitivity analysis confirmed the stability of the results and no publication bias was detected.

CONCLUSION:

Our outcomes showed that VDD increased the risk of developing anemia. More researches are warranted to clarify an understanding of the association between VDD and risk of anemia.

KEYWORDS:

Anemia; meta-analysis; vitamin D

PMID:
26329387
DOI:
10.3109/0886022X.2015.1052979
[Indexed for MEDLINE]

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