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World J Gastroenterol. 2015 Aug 28;21(32):9534-43. doi: 10.3748/wjg.v21.i32.9534.

Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis.

Author information

1
Yu-Ting Chang, Ming-Chu Chang, Shu-Chen Wei, Jau-Min Wong, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei 101, Taiwan.

Abstract

AIM:

To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis.

METHODS:

Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca(2+) signal and the expression of protein kinase C (PKC) were measured after treatment.

RESULTS:

Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca(2+) concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca(2+) concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.

CONCLUSION:

At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.

KEYWORDS:

Acute pancreatitis; Calcium; Hypertriglyceridemia; Saturated fatty acid; Unsaturated fatty acid

PMID:
26327761
PMCID:
PMC4548114
DOI:
10.3748/wjg.v21.i32.9534
[Indexed for MEDLINE]
Free PMC Article

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