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J Clin Invest. 2015 Sep;125(9):3335-7. doi: 10.1172/JCI83871. Epub 2015 Sep 1.

Cancer immunotherapy: harnessing the immune system to battle cancer.

Abstract

The recent clinical successes of immune checkpoint blockade and chimeric antigen receptor T cell therapies represent a turning point in cancer immunotherapy. These successes also underscore the importance of understanding basic tumor immunology for successful clinical translation in treating patients with cancer. The Reviews in this Review Series focus on current developments in cancer immunotherapy, highlight recent advances in our understanding of basic aspects of tumor immunology, and suggest how these insights can lead to the development of new immunotherapeutic strategies.

PMID:
26325031
PMCID:
PMC4588312
DOI:
10.1172/JCI83871
[Indexed for MEDLINE]
Free PMC Article

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