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Adv Exp Med Biol. 2015;850:73-80. doi: 10.1007/978-3-319-15774-0_6.

Mechanisms of Memory T Cell Activation and Effective Immunity.

Author information

1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA, gregoire.lauvau@einstein.yu.edu.

Abstract

Effective immunization induces the development of populations of robust effector lymphocytes specific for the immunizing antigens. Amongst them are cytotoxic/CD8(+)T lymphocytes, which few will further differentiate into long-lived memory cells persisting in the host and exhibiting improved functional characteristics. The current model is that such memory cells can confer rapid host protection upon cognate antigen-mediated activation and direct killing of infected cells. In this chapter, we discuss work from our group and others that highlight the contribution of inflammatory cytokines to memory CD8(+) T cell activation and of cytolysis-independent mechanisms of host protection.

PMID:
26324347
PMCID:
PMC4836952
DOI:
10.1007/978-3-319-15774-0_6
[Indexed for MEDLINE]
Free PMC Article

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