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Antimicrob Agents Chemother. 2015 Nov;59(11):7132-5. doi: 10.1128/AAC.01687-15. Epub 2015 Aug 31.

Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131.

Author information

1
VA Medical Center, Minneapolis, Minnesota, USA University of Minnesota, Minneapolis-Saint Paul, Minnesota, USA johns007@umn.edu.
2
VA Medical Center, Minneapolis, Minnesota, USA.
3
VA Medical Center, Minneapolis, Minnesota, USA University of Minnesota, Minneapolis-Saint Paul, Minnesota, USA.
4
University of Minnesota, Minneapolis-Saint Paul, Minnesota, USA.
5
George Washington University Milken Institute School of Public Health, Washington, DC, USA.
6
University of Washington, Seattle, Washington, USA.

Abstract

Minimum bactericidal concentrations (MBCs) for ciprofloxacin were significantly higher among 41 members of the H30 subclone within Escherichia coli sequence type 131 than among 48 other fluoroquinolone-resistant E. coli isolates. This MBC difference, which was not explained by ciprofloxacin MICs, gyrA, parC, and parE mutations, the presence of aac(6')-Ib-cr, or organic solvent tolerance (a surrogate for efflux pump activity), conceivably could have promoted the pandemic emergence of the H30 sequence type 131 subclone.

PMID:
26324269
PMCID:
PMC4604381
DOI:
10.1128/AAC.01687-15
[Indexed for MEDLINE]
Free PMC Article

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