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Nat Med. 2015 Oct;21(10):1139-41. doi: 10.1038/nm.3932. Epub 2015 Aug 31.

HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders.

Author information

1
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
2
Department of Global Health, University of Washington, Seattle, Washington, USA.
3
US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
4
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, USA.
5
Department of Medicine, University of Washington, Seattle, Washington, USA.
6
Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
7
Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
8
Thai Ministry of Public Health, Nonthaburi, Thailand.
9
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
10
Department of Microbiology, University of Washington, Seattle, Washington, USA.

Abstract

Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found--n two different cohorts--hat more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.

PMID:
26322580
PMCID:
PMC4598284
DOI:
10.1038/nm.3932
[Indexed for MEDLINE]
Free PMC Article

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