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ACS Chem Neurosci. 2015 Nov 18;6(11):1781-8. doi: 10.1021/acschemneuro.5b00189. Epub 2015 Sep 3.

Magnetic NGF-releasing PLLA/iron oxide nanoparticles direct extending neurites and preferentially guide neurites along aligned electrospun microfibers.

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Department of Chemistry and Biochemistry, University of California-San Diego , La Jolla, California 92093, United States.
Institute of Biomedical Engineering and Informatics (BMTI), Technische Universit├Ąt Ilmenau , G-Kirchhoff-Str. 2, D-98693 Ilmenau, Germany.
Department of Nano Biophotonics, Leibniz Institute of Photonic Technology (IPHT) , A.-Einstein-Str. 9, D-07745 Jena, Germany.


Nerve growth factor releasing composite nanoparticles (NGF-cNPs) were developed to direct the extension of neurite outgrowth from dorsal root ganglia (DRG). Iron oxide magnetic nanoparticles were incorporated into poly-l-lactic acid (PLLA) nanoparticles in order to position the NGF-cNPs in a culture dish. Neurites growing from DRG extended toward the NGF released from the NGF-cNPs. DRG were then cultured on aligned PLLA microfibers in the presence of NGF-cNPs, and these biomaterials combined to align DRG neurite extension along one axis and preferentially toward the NGF-cNPs. This combinatorial biomaterial approach shows promise as a strategy to direct the extension of regenerating neurites.


Poly-l-lactic acid; electrospun fiber; magnetic nanoparticle; nerve growth factor; neurite extension

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