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Hepat Mon. 2015 Aug 30;15(8):e29183. doi: 10.5812/hepatmon.29183. eCollection 2015 Aug.

Low Serum Hepatitis B Surface Antigen Level Predicts Compensated Cirrhosis Caused by Chronic Hepatitis B in HBeAg Positive Patients in East China.

Author information

1
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China ; Department of Infectious Diseases, Jing'An District Centre, Shanghai Hospital, Fudan University, Shanghai, China.
2
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
3
Department of Infectious Diseases, Jing'An District Centre, Shanghai Hospital, Fudan University, Shanghai, China.
4
Department of Liver Diseases, Xixi Hospital of Hangzhou, Zhejiang Chinese Medical University, Hangzhou, China.

Abstract

BACKGROUNDS:

Serum hepatitis B surface antigen (HBsAg) levels are associated with fibrosis in patients with chronic hepatitis B (CHB) infection.

OBJECTIVES:

The aim of our study was to evaluate serum HBsAg level as a biomarker for compensated cirrhosis in hepatitis B e antigen (HBeAg) positive CHB patients.

PATIENTS AND METHODS:

Two-hundred and one HBeAg-positive Chinese CHB patients with or without cirrhosis were enrolled in this retrospective study. Cirrhosis was diagnosed based on liver biopsy. Furthermore, patients with decompensated cirrhosis were excluded. A statistical analysis was performed regarding the association between serum HBsAg level and compensated cirrhosis.

RESULTS:

Patients with compensated cirrhosis had a significantly lower mean serum HBsAg level compared to those without cirrhosis (3.27 Log10 IU/mL VS 4.17 Log10 IU/mL, P < 0.001). Furthermore, examining the correlation with compensated cirrhosis revealed that lower level of serum HBsAg was a significant factor in multivariate analysis. The area under the receiver operating characteristics curve of serum HBsAg was 0.856 for compensated cirrhosis. A positive predictive value of 66.2% and negative predictive value of 90.7% were obtained with a cut-off value of < 3.60 Log10 IU/mL (4000 IU/mL) of serum HBsAg. Moreover, the rate of compensated cirrhosis increased to 75.0% after combining with APRI > 2.

CONCLUSIONS:

In HBeAg positive CHB patients, low serum HBsAg level is a useful predictor of compensated cirrhosis.

KEYWORDS:

Chronic; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B e Antigens; Liver Cirrhosis

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