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Am J Orthod Dentofacial Orthop. 2015 Sep;148(3):450-6. doi: 10.1016/j.ajodo.2015.04.031.

Effect of fluoxetine on induced tooth movement in rats.

Author information

1
Postgraduate student, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
2
Professor, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
3
Professor, Graduate Program in Dentistry, Histopathology, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil.
4
Professor, Graduate Program in Dentistry, Orthodontics, School of Health and Biosciences, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil. Electronic address: escamargo@uol.com.br.

Abstract

INTRODUCTION:

Fluoxetine is a widely used antidepressant. Its various effects on bone mineral density are well described. The aim of this study was to evaluate the effect of fluoxetine on induced tooth movement.

METHODS:

Seventy-two Wistar rats were divided into 3 groups: M (n = 24; 0.9% saline solution and induced tooth movement), FM (n = 24; fluoxetine, 10 mg/kg, and induced tooth movement), and F (n = 24; fluoxetine, 10 mg/kg only). After 30 days of daily saline solution or fluoxetine administration, an orthodontic appliance (30 cN) was used to displace the first molar mesially in groups M and FM. The animals were killed 3, 7, and 14 days after placement of the orthodontic appliances. The animals in group F did not receive induced tooth movement but were killed at the same times. We evaluated tooth movement rates, collagen neoformation rates by polarization microscopy, numbers of osteoclast by tartrate-resistant acid phosphatase, and trabecular bone modeling by microcomputed tomography of the femur.

RESULTS:

The tooth movement rates were similar in groups M and FM at all studied time points (P >0.05). The rate of newly formed collagen had a reverse pattern in groups M and FM, but the difference was not statistically significant (P >0.05). There were significantly more osteoclasts in group FM than in group F on day 3 (P <0.01). The trabecular spacing was significantly larger in group F compared with group M on day 14 (P <0.05).

CONCLUSIONS:

Fluoxetine did not interfere with induced tooth movement or trabecular bone in rats.

PMID:
26321343
DOI:
10.1016/j.ajodo.2015.04.031
[Indexed for MEDLINE]

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