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J Extracell Vesicles. 2015 Aug 28;4:27494. doi: 10.3402/jev.v4.27494. eCollection 2015.

Biogenesis, delivery, and function of extracellular RNA.

Author information

1
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA; James.G.Patton@Vanderbilt.edu.
2
VA Medical Center, Nashville, TN, USA.
3
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
4
Department of Medicine, Vanderbilt University, Nashville, TN, USA.
5
Department of Cancer Biology, Vanderbilt University, Nashville, TN, USA.
6
Department of Cardiology, Vanderbilt University, Nashville, TN, USA.
7
Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
8
Department of Microbiology & Immunology, University of California San Francisco, San Francisco, CA, USA.
9
Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA, USA.
10
Department of Urology, University of California San Francisco, San Francisco, CA, USA.
11
Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
12
Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA, USA.
13
Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
14
Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.
15
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
16
Department of Surgery, University of California San Francisco, San Francisco, CA, USA.
17
VA Medical Center, San Francisco, CA, USA.
18
Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.
19
Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA.
20
Harvard Medical School, Boston, MA, USA.
21
Swiss Federal Institute of Technology Zürich (ETH Zürich), Zürich, Switzerland.
22
Diabetes Center, University of California San Francisco, San Francisco, CA, USA.
23
Harvard University, Cambridge, MA, USA.

Abstract

The Extracellular RNA (exRNA) Communication Consortium was launched by the National Institutes of Health to focus on the extent to which RNA might function in a non-cell-autonomous manner. With the availability of increasingly sensitive tools, small amounts of RNA can be detected in serum, plasma, and other bodily fluids. The exact mechanism(s) by which RNA can be secreted from cells and the mechanisms for the delivery and uptake by recipient cells remain to be determined. This review will summarize current knowledge about the biogenesis and delivery of exRNA and outline projects seeking to understand the functional impact of exRNA.

KEYWORDS:

ERCC; exRNA; extracellular RNA

PMID:
26320939
PMCID:
PMC4553266

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