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Genome Biol. 2015 Aug 29;16:182. doi: 10.1186/s13059-015-0752-8.

Predicting the spatial organization of chromosomes using epigenetic data.

Author information

1
Laboratory of Molecular Biology of Eukaryotes (LBME), CNRS - University of Toulouse (UPS), F-31000, Toulouse, France.
2
Laboratory of Molecular Biology of Eukaryotes (LBME), CNRS - University of Toulouse (UPS), F-31000, Toulouse, France. cuvier@ibcg.biotoul.fr.

Abstract

Chromosome folding can reinforce the demarcation between euchromatin and heterochromatin. Two new studies show how epigenetic data, including DNA methylation, can accurately predict chromosome folding in three dimensions. Such computational approaches reinforce the idea of a linkage between epigenetically marked chromatin domains and their segregation into distinct compartments at the megabase scale or topological domains at a higher resolution. Please see related articles: http://dx.doi.org/10.1186/s13059-015-0741-y and http://dx.doi.org/10.1186/s13059-015-0740-z.

PMID:
26319942
PMCID:
PMC4552987
DOI:
10.1186/s13059-015-0752-8
[Indexed for MEDLINE]
Free PMC Article

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