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Curr Opin Biotechnol. 2015 Dec;36:32-9. doi: 10.1016/j.copbio.2015.08.001. Epub 2015 Aug 28.

Engineering of oleaginous organisms for lipid production.

Author information

1
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.
2
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: kzengler@ucsd.edu.

Abstract

Phototrophs are attractive candidates for commercial lipid production. Lipid biosynthetic pathways in these organisms have been largely characterized but the mechanisms partitioning resources toward storage lipids are poorly understood. One promising strategy to study and enhance biomass lipid bioproduction in oleaginous microorganisms is to combine genome-scale metabolic modeling and genetic and metabolic engineering. Here we describe recent advances in in vitro, in vivo, and in silico manipulations of phototrophic metabolism that increase total lipid content or redirect lipid production toward more favorable products such as polyunsaturated fatty acids used as nutritional supplements or in biofuel production.

PMID:
26319892
DOI:
10.1016/j.copbio.2015.08.001
[Indexed for MEDLINE]

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