Send to

Choose Destination
See comment in PubMed Commons below
J Interv Card Electrophysiol. 2015 Dec;44(3):273-7. doi: 10.1007/s10840-015-0046-9. Epub 2015 Aug 30.

Nuclear image-guided left ventricular pacing lead navigation feasibility of a new technique.

Author information

  • 1Division of Radiology, University of Pittsburgh, Pittsburgh, PA, USA.
  • 2QuantMD, LLC, Pittsburgh, PA, USA.
  • 3Heart, Lung and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.



Current techniques for left ventricular (LV) lead implantation in patients with ischemic cardiomyopathy (ICM) typically underutilize information which is important for optimal lead location, including LV mechanical activation pattern and scar location. We sought to develop a technique in which this information, contained in single-photon emission computed tomographic (SPECT) images, could be integrated as to guide the electrophysiologist during the implantation procedure.


Five ICM patients underwent SPECT as well as multidetector cardiac computed tomographic (MDCT) imaging prior to the LV lead implantation procedure. Images were merged to create a "fusion" image, in which the SPECT data were projected onto the anatomically accurate MDCT epicardial surface. The fusion image was registered to the operative field using the coronary veins, apparent on the MDCT image, as a fiducial system. After registration, LV lead implantation was guided by the fusion image using a commercial catheter navigation system.


Successful guidance was achieved in each patient, with minimal disturbance to standard workflow. Leads were implanted in late-activating, unscarred regions according to the fusion image, with locations corroborated by fluoroscopic and electrographic features. In regions where leads were contiguous to the phrenic nerve shown on the fusion image, pacing consistently demonstrated diaphragmatic stimulation.


In this technical report, the description and feasibility of a new technique for SPECT image-guided LV pacing lead navigation is demonstrated. Prospective study will be required to confirm image precision and registration/navigation accuracy, as well as to demonstrate value relative to standard implantation techniques.


Cardiac resynchronization therapy; Computed tomography; Heart failure; Image guidance; Pacing; Single-photon emission computed tomography

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center