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Bioorg Med Chem Lett. 2015 Nov 1;25(21):4753-4756. doi: 10.1016/j.bmcl.2015.07.099. Epub 2015 Aug 7.

Synthesis of new kojic acid based unnatural α-amino acid derivatives.

Author information

1
Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India; Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530045, AP, India.
2
Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India.
3
Department of Chemistry, GITAM Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530045, AP, India.
4
Medicinal Chemistry Department, GVK Biosciences Pvt. Ltd, Survey Nos: 125 (Part) & 126, IDA, Mallapur, Hyderabad 500076, Telangana, India. Electronic address: Manoranjan.Behera@gvkbio.com.

Abstract

An efficient method for the preparation of kojic acid based α-amino acid derivatives by alkylation of glycinate schiff base with bromokojic acids have been described. Using this method, mono as well as di alkylated kojic acid-amino acid conjugates have been prepared. This is the first synthesis of C-linked kojic acid-amino acid conjugate where kojic acid is directly linked to amino acid through a C-C bond.

KEYWORDS:

Alkylation; Glycine; Hybrid molecule; Kojic acid; Unnatural amino acid

PMID:
26318994
DOI:
10.1016/j.bmcl.2015.07.099
[Indexed for MEDLINE]

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