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Eur Radiol. 2016 May;26(5):1254-62. doi: 10.1007/s00330-015-3932-8. Epub 2015 Aug 30.

Cerebrospinal fluid volumetric MRI mapping as a simple measurement for evaluating brain atrophy.

Author information

1
Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands. j.devis-2@umcutrecht.nl.
2
Department of Radiology, University Medical Center Utrecht, HP E 01.132, P.O.Box 85500, 3508, GA, Utrecht, The Netherlands.
3
Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
4
Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, Hvidovre, Denmark.

Abstract

OBJECTIVES:

To assess whether volumetric cerebrospinal fluid (CSF) MRI can be used as a surrogate for brain atrophy assessment and to evaluate how the T2 of the CSF relates to brain atrophy.

METHODS:

Twenty-eight subjects [mean age 64 (sd 2) years] were included; T1-weighted and CSF MRI were performed. The first echo data of the CSF MRI sequence was used to obtain intracranial volume, CSF partial volume was measured voxel-wise to obtain CSF volume (VCSF) and the T2 of CSF (T2,CSF) was calculated. The correlation between VCSF/T2,CSF and brain atrophy scores [global cortical atrophy (GCA) and medial temporal lobe atrophy (MTA)] was evaluated.

RESULTS:

Relative total, peripheral subarachnoidal, and ventricular VCSF increased significantly with increased scores on the GCA and MTA (R = 0.83, 0.78 and 0.78 and R = 0.72, 0.62 and 0.86). Total, peripheral subarachnoidal, and ventricular T2 of the CSF increased significantly with higher scores on the GCA and MTA (R = 0.72, 0.70 and 0.49 and R = 0.60, 0.57 and 0.41).

CONCLUSION:

A fast, fully automated CSF MRI volumetric sequence is an alternative for qualitative atrophy scales. The T2 of the CSF is related to brain atrophy and could thus be a marker of neurodegenerative disease.

KEY POINTS:

• A 1:11 min CSF MRI volumetric sequence can evaluate brain atrophy. • CSF MRI provides accurate atrophy assessment without partial volume effects. • CSF MRI data can be processed quickly without user interaction. • The measured T 2 of the CSF is related to brain atrophy.

KEYWORDS:

Brain atrophy; Brain volume; Cerebrospinal fluid; Imaging; Magnetic resonance imaging

PMID:
26318506
PMCID:
PMC4820466
DOI:
10.1007/s00330-015-3932-8
[Indexed for MEDLINE]
Free PMC Article

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