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Trends Neurosci. 2015 Sep;38(9):524-34. doi: 10.1016/j.tins.2015.07.008. Epub 2015 Aug 25.

The neuronal identity bias behind neocortical GABAergic plasticity.

Author information

1
Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France.
2
Sorbonne Universités, Université Pierre et Marie Curie (UPMC Paris 6), Unité Mixte de Recherche S 1127; Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 1127; Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7225; Institut du Cerveau et de la Moelle épinière (ICM), 75013 Paris, France. Electronic address: alberto.bacci@icm-institute.org.

Abstract

In the neocortex, different types of excitatory and inhibitory neurons connect to one another following a detailed blueprint, defining functionally-distinct subnetworks, whose activity and modulation underlie complex cognitive functions. We review the cell-autonomous plasticity of perisomatic inhibition onto principal excitatory neurons. We propose that the tendency of different cortical layers to exhibit depression or potentiation of perisomatic inhibition is dictated by the specific identities of principal neurons (PNs). These are mainly defined by their projection targets and by their preference to be innervated by specific perisomatic-targeting basket cell types. Therefore, principal neurons responsible for relaying information to subcortical nuclei are differentially inhibited and show specific forms of plasticity compared to other PNs that are specialized in more associative functions.

KEYWORDS:

GABAergic plasticity; inhibition; neocortex; retrograde signaling

PMID:
26318208
DOI:
10.1016/j.tins.2015.07.008
[Indexed for MEDLINE]

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