Format

Send to

Choose Destination
Oncotarget. 2015 Oct 6;6(30):29076-86. doi: 10.18632/oncotarget.4931.

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer.

Author information

1
Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Abstract

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.

KEYWORDS:

3-phosphoinositide-dependent protein kinase 1; JunB; epithelial–mesenchymal transition; invasion; migration

PMID:
26318166
PMCID:
PMC4745712
DOI:
10.18632/oncotarget.4931
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Impact Journals, LLC Icon for PubMed Central
Loading ...
Support Center