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Oncotarget. 2015 Sep 22;6(28):25418-28. doi: 10.18632/oncotarget.4456.

MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.

Author information

1
Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
2
Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P.R. China.
3
Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P.R. China.
4
Department of Medical Oncology, Shanghai Tianyou Hospital of Tongji University, Shanghai, 200032, P.R. China.

Abstract

Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.

KEYWORDS:

ZNF24; epithelial-mesenchymal transition; gastric cancer; metastasis; miR-940

PMID:
26317898
PMCID:
PMC4694841
DOI:
10.18632/oncotarget.4456
[Indexed for MEDLINE]
Free PMC Article

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