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J Psychoactive Drugs. 2015 Sep-Oct;47(4):286-92. doi: 10.1080/02791072.2015.1073815. Epub 2015 Aug 28.

The Association of Salvia divinorum and Psychotic Disorders: A Review of the Literature and Case Series.

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a Consultant Adult and Addiction Psychiatrist, Department of Psychiatry , American University of Beirut Medical Center , Beirut , Lebanon.
b PGY-4 Psychiatry, Department of Psychiatry and Clinical Psychology , St. George Hospital University Medical Center , Beirut , Lebanon.


The association of substance abuse and psychotic disorders is of interest to clinicians, academics, and lawmakers. Commonly abused substances, such as cannabis, cocaine, amphetamines, and alcohol, have all been associated with substance-induced psychosis. Hallucinogens can induce desired psychedelic effects and undesirable psychomimetic reactions. These are usually transient and resolve once the duration of action is over. Sometimes, these effects persist, causing distress and requiring intervention. This article focuses on the hallucinogenic substance Salvia divinorum, the use of which has been observed, particularly among youth worldwide. We present background information based on a review of the literature and on our own clinical encounters, as highlighted by two original case reports. We hypothesize that consumption of Salvia divinorum could be associated with the development of psychotic disorders. We propose that clinicians routinely inquire about the use of Salvia in patients with substance use disorders or psychotic illnesses. More research is required to assess any relationship between Salvia divinorum and psychosis. Additionally, we advocate increased public and medical awareness of this substance and other emerging drugs of abuse.


Salvia divinorum; Salvinorin A; hallucinogen; psychosis; substance-induced psychosis (SIP)

[Indexed for MEDLINE]

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