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Cell. 2015 Aug 27;162(5):948-59. doi: 10.1016/j.cell.2015.08.008.

Architectural and Functional Commonalities between Enhancers and Promoters.

Author information

1
Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: taekyung.kim@utsouthwestern.edu.
2
University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Department of Human Genetics, Biomedical Research Building, Room 719, 1501 NW 10(th) Avenue, Miami, FL 33136, USA. Electronic address: rshiekhattar@med.miami.edu.

Abstract

With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.

PMID:
26317464
PMCID:
PMC4556168
DOI:
10.1016/j.cell.2015.08.008
[Indexed for MEDLINE]
Free PMC Article

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