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Nutr Cancer. 2015;67(7):1120-30. doi: 10.1080/01635581.2015.1073757. Epub 2015 Aug 28.

Association Between Prediagnostic Serum 25-Hydroxyvitamin D Concentration and Glioma.

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a Comprehensive Cancer Center and Division of Epidemiology, College of Public Health , Ohio State University , Columbus , Ohio , USA.
b Division of Epidemiology , College of Public Health, Ohio State University , Columbus , Ohio , USA.
c Nationwide Children's Hospital , Columbus , Ohio , USA.
d Division of Biostatistics, College of Public Health and Mathematical Biosciences Institute , Ohio State University , Columbus , Ohio , USA.
e Department of Statistics , Ohio State University , Columbus , Ohio , USA.
f Vitas Analytic Services , Oslo , Norway.
g Institute of Environmental Medicine , Division of Epidemiology, Karolinska Institutet , Stockholm , Sweden.
h Department of Registration , Cancer Registry of Norway , Oslo , Norway.


There are no previous studies of the association between prediagnostic serum vitamin D concentration and glioma. Vitamin D has immunosuppressive properties; as does glioma. It was, therefore, our hypothesis that elevated vitamin D concentration would increase glioma risk. We conducted a nested case-control study using specimens from the Janus Serum Bank cohort in Norway. Blood donors who were subsequently diagnosed with glioma (n = 592), between 1974 and 2007, were matched to donors without glioma (n = 1112) on date and age at blood collection and sex. We measured 25-hydroxyvitamin D [25(OH)D], an indicator of vitamin D availability, using liquid chromatography coupled with mass spectrometry. Seasonally adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated for each control quintile of 25(OH)D using conditional logistic regression. Among men diagnosed with high grade glioma >56, we found a negative trend (P = .04). Men diagnosed ≤ 56 showed a borderline positive trend (P = .08). High levels (>66 nmol/L) of 25(OH)D in men >56 were inversely related to high grade glioma from ≥2 yr before diagnosis (OR = 0.59; 95% CI = 0.38, 0.91) to ≥15 yr before diagnosis (OR = 0.61; 95% CI = 0.38,0.96). Our findings are consistent long before glioma diagnosis and are therefore unlikely to reflect preclinical disease.

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