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Curr Transplant Rep. 2015 Jun 1;2(2):202-210.

New Tools in Experimental Cellular Therapy for the Treatment of Liver Diseases.

Author information

1
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ; Department of Chemistry, Northwestern University, Evanston, IL 60201, USA ; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60201, USA ; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60201, USA ; Simpson Querrey Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 60611, USA.
2
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ; Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 676 St. Clair St. Suite 1900, Chicago, IL 60611, USA.
3
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ; Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60201, USA ; International Institute for Nanotechnology, Northwestern University, Evanston, IL 60201, USA ; Simpson Querrey Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, IL 60611, USA ; Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, 676 St. Clair St. Suite 1900, Chicago, IL 60611, USA ; Department of Surgery, Jesse Brown VA Medical Center, Chicago, IL 60612, USA ; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60201, USA.

Abstract

The current standard of care for end stage liver disease is orthotopic liver transplantation (OLT). Through improvement in surgical techniques, immunosuppression, and general medical care, liver transplantation has become an effective treatment over the course of the last half-century. Unfortunately, due to the limited availability of donor organs, there is a finite limit to the number of patients who will benefit from this therapy. This review will discuss current research in experimental cellular therapies for acute, chronic, and metabolic liver failure that may be appropriate when liver transplantation is not an immediate option.

KEYWORDS:

Alternative cell sources; Cellular therapy; Hepatocyte transplantation; Stem cells

PMID:
26317066
PMCID:
PMC4547556

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