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Endocrinol Metab Clin North Am. 2015 Sep;44(3):663-76. doi: 10.1016/j.ecl.2015.05.011. Epub 2015 Jun 20.

Regulation of Body Composition and Bioenergetics by Estrogens.

Author information

1
Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mailstop B179, Academic Office One, 12631 East 17th Avenue, Room 8111, Aurora, CO 80045, USA.
2
Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Mailstop B179, Academic Office One, 12631 East 17th Avenue, Room 8111, Aurora, CO 80045, USA. Electronic address: wendy.kohrt@ucdenver.edu.

Abstract

Evidence points to an important role of estradiol (E2) in the regulation of body composition and bioenergetics. Basic and preclinical research shows that the disruption of E2 signaling through either genetic manipulation or surgical intervention accelerates fat accumulation, with a disproportionate increase in abdominal fat. Clinical evidence for the regulation of body composition and bioenergetics by E2 is less consistent. Evidence exists both for and against menopause as the mediator of changes in body composition. Thus, a need remains to better understand the metabolic actions of estrogens in women and the potential impact on health after the menopause.

KEYWORDS:

Adiposity; Body composition; Energy expenditure; Energy intake; Estradiol; Estrogen receptor; Menopause; Ovariectomy

PMID:
26316249
PMCID:
PMC4555869
DOI:
10.1016/j.ecl.2015.05.011
[Indexed for MEDLINE]
Free PMC Article

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