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J Neurosurg. 2016 Mar;124(3):861-5. doi: 10.3171/2015.2.JNS142668. Epub 2015 Aug 28.

Malignant fungal infection of the cavernous sinus: case report.

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Department of Neurosurgery; and.
Department of Surgery, Division of Otolaryngology, University of Utah School of Medicine, Salt Lake City, Utah.


Intracranial spread of fungal infection is a life-threatening condition that usually affects immunocompromised patients. Here the authors present a case of biopsy-proven Aspergillus fumigatus infection of the paranasal sinuses in an immunocompetent patient with documented spread to the orbit, cavernous sinus, and petrous apex despite medical antifungal treatment. As a life-saving treatment, cavernous sinus resection with external carotid artery-middle cerebral artery bypass was performed. The authors discuss the literature regarding the intracranial spread of paranasal sinus fungal infections in immunocompetent patients and management strategies.


Aspergillus fumigatus; CCA = common carotid artery; ECA = external carotid artery; ECA-MCA bypass; ICA = internal carotid artery; MCA = middle cerebral artery; cavernous sinus infection; cavernous sinus resection; paranasal fungal infection

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