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Pediatr Nephrol. 2016 Jan;31(1):131-6. doi: 10.1007/s00467-015-3191-6. Epub 2015 Aug 28.

High prevalence of elevated blood pressure among children with neurofibromatosis type 1.

Author information

1
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
2
The Gilbert Israeli Neurofibromatosis Center, Tel-Aviv Medical Center, Tel-Aviv, Israel.
3
Nephrology Department, Tel-Aviv Medical Center, Tel-Aviv, Israel.
4
Pediatric Nephrology Service, Tel-Aviv Medical Center, Tel-Aviv, Israel.
5
Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. shayb@tlvmc.gov.il.
6
The Gilbert Israeli Neurofibromatosis Center, Tel-Aviv Medical Center, Tel-Aviv, Israel. shayb@tlvmc.gov.il.

Abstract

BACKGROUND:

Neurofibromatosis type 1 (NF1) is a common neurocutaneous disease characterized by café-au-lait spots, axillary and inguinal freckling, neurofibromas, and optic gliomas. Increased rates of hypertension (HTN) were reported among NF1 patients, however, the prevalence of HTN and pre-HTN in pediatric NF1 patients has not been clarified.

METHODS:

Blood pressure (BP) measurements, weight, and renal ultrasound were assessed in 224 NF1 pediatric patients followed in a specialized NF1 clinic.

RESULTS:

The cohort's mean age was 9.1 ± 4.1 years. Overweight and obesity were found in 12.9 and 10.3 % of them, respectively. BP was measured averagely 2.9 times per patient on different occasions. Blood pressure was in the pre-HTN and HTN ranges in 14.9 and 16.9 % of measurements, respectively. BP >95th was detected in 20.5 % at the first measurement. Of 114 children with at least three BP measurements, 18.4 % had two values in the HTN range and 6.14 % had at least three. Overweight was not associated with HTN among children with NF1. Urinary tract ultrasonographic abnormalities were detected in 6.8 % (11/161) of cases.

CONCLUSIONS:

The prevalence of increased BP in pediatric NF1 is much higher than in the general pediatric population. BP has to be regularly assessed and managed in this high-risk population.

KEYWORDS:

Hypertension; NF1; Obesity; Pre-hypertension; Renal ultrasound

PMID:
26314566
DOI:
10.1007/s00467-015-3191-6
[Indexed for MEDLINE]

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