Format

Send to

Choose Destination
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Aug;23(4):1017-20. doi: 10.7534/j.issn.1009-2137.2015.04.021.

[Distribution of CD45RO⁺ T and CD45RA⁺ T Cells in Peripheral Blood of Patients with Peripheral T Cell Lymphoma].

[Article in Chinese]

Author information

1
Department of Oncology and Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
2
Department of Oncology and Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China . E-mail: jiaxinyan100@163.com.

Abstract

OBJECTIVE:

To investigate the clinical significance of memory T cells (CD45RO⁺ T) and the initial T cells (CD45RA⁺ T) distribution in peripheral blood of patients with peripheral T-cell lymphoma (PTCL).

METHODS:

A total of 27 patients diagnosed as PTCL in our hospital from February 2010 to February 2014 were collected in this study; whereas 30 healthy people were enrolled as control. The distribution of CD45RO⁺ T and CD45RA⁺ T cells were detected seperately in each group, and the results were analysed further.

RESULTS:

The expression of T cell antigens in lymphnodes of PTCL patients were diverse: the CD4⁺ T cells were the main immune phenotype, while the B cell-related antigen was not expressed. The CD4⁺/CD8⁺, CD4⁺ CD45RO⁺ T in the peripheral blood of PTCL patients were significantly lower than that in normal group (P < 0.05); while the CD4, CD45RA⁺ T, CD8⁺ CD45RA⁺ T and CD8⁺ CD45RO⁺ T were significantly higher than that in normal group (P < 0.05). The patients in stage I/II had higher CD4⁺/CD8⁺, CD4⁺ CD45RO⁺ T than those in stage III/IV (P < 0.05), whereas the CD4⁺ CD45RA⁺ T, CD8⁺ CD45RA⁺ T and CD8⁺ CD45RO⁺ T were significantly lower than those in the stage III/IV patients (P < 0.05).

CONCLUSION:

The distributions of CD45RA⁺ T and CD45RO⁺ T in PTCL patients are quite different, and the corresponding treatment might be adopted according to the different distribution of these cells, so as to improve the diagnosis and prognosis of PTCL.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center