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J Leukoc Biol. 2015 Dec;98(6):931-6. doi: 10.1189/jlb.3VMR0415-142R. Epub 2015 Aug 26.

YKL-40/CHI3L1 drives inflammation on the road of tumor progression.

Author information

1
Department of Biomedical Sciences, College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA.
2
Department of Biomedical Sciences, College of Medicine, Florida Atlantic University, Boca Raton, Florida, USA iragavar@fau.edu.

Abstract

Inflammation plays a vital role at different stages of tumor progression. The development of tumors is affected by inflammatory mediators produced by the tumor and the host. YKL-40/chitinase-3-like-1 protein is often up-regulated in inflammation-associated diseases. With the use of chronic inflammatory disease systems, we describe the role of YKL-40/chitinase-3-like-1 protein in enhancing the inflammatory response and its implications in tumorigenesis. We also discuss how pre-existing inflammation enhances tumor growth and metastasis. In this mini-review, we highlight the effect of YKL-40/chitinase-3-like-1 protein-associated inflammation in promoting tumor progression.

KEYWORDS:

angiogenesis; cytokines; inflammatory bowel; pulmonary inflammation

PMID:
26310833
PMCID:
PMC6608021
DOI:
10.1189/jlb.3VMR0415-142R
[Indexed for MEDLINE]
Free PMC Article

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