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J Infect Dis. 2016 Feb 15;213(4):569-73. doi: 10.1093/infdis/jiv425. Epub 2015 Aug 26.

Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation.

Author information

1
Division of Experimental Medicine, University of California-San Francisco.
2
Gladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, California.
3
Department of Medicine, University of California-San Francisco Gladstone Institute of Virology and Immunology, Gladstone Institutes, San Francisco, California.
4
Division of Clinical Immunology and Allergy, University of São Paulo, Brazil.
5
Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington D.C.

Abstract

We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+) T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk.

KEYWORDS:

HESN; HIV-1; T-cell activation; infection risk

PMID:
26310308
PMCID:
PMC4721903
DOI:
10.1093/infdis/jiv425
[Indexed for MEDLINE]
Free PMC Article

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