Format

Send to

Choose Destination
Prog Mol Biol Transl Sci. 2015;134:249-67. doi: 10.1016/bs.pmbts.2015.06.013. Epub 2015 Jul 15.

Molecular and Biochemical Aspects of the Retina on Refraction.

Author information

1
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
2
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: mpardue@emory.edu.

Abstract

Mutant mouse models with specific visual pathway defects offer an advantage to comprehensively investigate the role of specific pathways/neurons involved in refractive development. In this review, we will focus on recent studies using mouse models that have provided insight into retinal pathways and neurotransmitters controlling refractive development. Specifically, we will examine the contributions of rod and cone photoreceptors and the ON and OFF retinal pathways to visually driven eye growth with emphasis on dopaminergic mechanisms.

KEYWORDS:

Form deprivation; Mice; Myopia; OFF bipolar cells; ON bipolar cells; Photoreceptors; Refraction

PMID:
26310159
PMCID:
PMC5588150
DOI:
10.1016/bs.pmbts.2015.06.013
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center