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Prog Mol Biol Transl Sci. 2015;134:241-8. doi: 10.1016/bs.pmbts.2015.05.005. Epub 2015 Jun 12.

Scleral Mechanisms Underlying Ocular Growth and Myopia.

Author information

1
School of Optometry, University of California, Berkeley, California, USA. Electronic address: metlapally@berkeley.edu.
2
School of Optometry, University of California, Berkeley, California, USA.

Abstract

In the regulation of ocular growth, scleral events critically determine eye size and thus the refractive status of the eye. Increased scleral matrix remodeling can lead to exaggerated eye growth causing myopia and additionally increased risk of ocular pathological complications. Thus, therapies targeting these changes in sclera hold potential to limit such complications since sclera represents a relatively safe and accessible drug target. Understanding the scleral molecular mechanisms underlying ocular growth is essential to identifying plausible therapeutic targets in the sclera. This section provides a brief update on molecular studies that pertain to the sclera in the context of ocular growth regulation and myopia.

KEYWORDS:

Eye growth; Myopia; Sclera

PMID:
26310158
PMCID:
PMC4687967
DOI:
10.1016/bs.pmbts.2015.05.005
[Indexed for MEDLINE]
Free PMC Article

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