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Vestn Oftalmol. 2015 May-Jun;131(3):76-81. doi: 10.17116/oftalma2015131376-81.

[Evaluating the effectiveness of Solanum tuberosum shoots extract in experimental ocular herpes].

[Article in Russian; Abstract available in Russian from the publisher]

Author information

1
Research Institute of Virology named after D.I. Ivanovsky, Ministry of Health of the Russian Federation, 16 Gamalei St., Moscow, Russian Federation, 123098.
2
Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygina St., Moscow, Russian Federation, 119991.

Abstract

in English, Russian

Ocular herpes (OH) is an infectious disease caused by the herpes simplex virus (HSV) characterized by a variable clinical presentation and often accompanied by complications that may lead to deterioration of visual functions, cataract development, or even blindness. Its treatment is arduous. The aim of this work was to evaluate the effectiveness, tolerability, and safety of Panavir eye drops in a rabbit model of OH.

MATERIAL AND METHODS:

Ocular infection was induced with HSV-1 (EU strain) in grey rabbits (all males, 2.5-3.0 kg) according to the standard technique. The treatment included Panavir-GLA (Panavir-gamma-linolenic acid) and Panavir medications.

RESULTS:

Panavir eye drops instilled 6 times daily for 8 days showed a pronounced therapeutic effect and prevented the development of severe corneal opacities. The most rapid and significant results were seen in rabbits with epithelial keratitis and those with short-term persistence of the virus. Generally, the effectiveness of Panavir eye drops was comparable with that of the reference drug (Oftalmoferon). Panavir instillations caused no irritation, toxic and/or allergic effects and were well tolerated by the rabbits.

CONCLUSION:

The data obtained suggest that Panavir eye drops may be included in OH treatment schemes.

PMID:
26310012
DOI:
10.17116/oftalma2015131376-81
[Indexed for MEDLINE]

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