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Int J Clin Exp Med. 2015 Jun 15;8(6):9291-8. eCollection 2015.

Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer.

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Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
Department of Laboratory Medicine, General Hospital of Jinan Military Area Jinan 250031, China.
Department of Neurosurgery, The Fourth Hospital of Jinan Jinan 250031, China.



Non-small-cell lung cancer (NSCLC) is one of the leading causes of death. The aim of the present study was to compare the expression of let-7c and miR-152 in surgically resected NSCLC cases and healthy cases to evaluate their diagnostic impact.


This hospital-based case-control study included 120 NSCLC patients and 360 healthy controls. The miRNA levels were measured via quantitative reverse transcription-polymerase chain reaction and their association with NSCLC was assessed by statistical data analysis and receiver operating characteristic curves.


The expression of let-7c and miR-152 in plasma were found to be downregulated in the patients with NSCLC. Advanced studies showed that the plasma let-7c and miR-152 were correlated with the clinicopathological features such as histological classifications, differentiation status, lymph node metastasis and stage classifications. The ROC curves for the miRNAs revealed a strong diagnostic performance. ROC curve analyses revealed that both plasma let-7c and miR-152 could serve as valuable biomarkers for NSCLC cases from healthy controls with an AUC of 0.714 and 0.845.


It was found that let-7c and miR-152 are significantly reduced in plasma samples of NSCLC patients. These findings suggest that detection of circulating let-7c and miR-152 can be developed into a noninvasive and rapid diagnostic tool for the individuals with NSCLC.


biomarker; diagnosis; miRNA; non-small-cell lung cancer


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