Format

Send to

Choose Destination
Int J Clin Exp Med. 2015 Jun 15;8(6):9291-8. eCollection 2015.

Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer.

Author information

1
Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, China.
2
Department of Laboratory Medicine, General Hospital of Jinan Military Area Jinan 250031, China.
3
Department of Neurosurgery, The Fourth Hospital of Jinan Jinan 250031, China.

Abstract

BACKGROUND:

Non-small-cell lung cancer (NSCLC) is one of the leading causes of death. The aim of the present study was to compare the expression of let-7c and miR-152 in surgically resected NSCLC cases and healthy cases to evaluate their diagnostic impact.

METHODS:

This hospital-based case-control study included 120 NSCLC patients and 360 healthy controls. The miRNA levels were measured via quantitative reverse transcription-polymerase chain reaction and their association with NSCLC was assessed by statistical data analysis and receiver operating characteristic curves.

RESULTS:

The expression of let-7c and miR-152 in plasma were found to be downregulated in the patients with NSCLC. Advanced studies showed that the plasma let-7c and miR-152 were correlated with the clinicopathological features such as histological classifications, differentiation status, lymph node metastasis and stage classifications. The ROC curves for the miRNAs revealed a strong diagnostic performance. ROC curve analyses revealed that both plasma let-7c and miR-152 could serve as valuable biomarkers for NSCLC cases from healthy controls with an AUC of 0.714 and 0.845.

CONCLUSION:

It was found that let-7c and miR-152 are significantly reduced in plasma samples of NSCLC patients. These findings suggest that detection of circulating let-7c and miR-152 can be developed into a noninvasive and rapid diagnostic tool for the individuals with NSCLC.

KEYWORDS:

biomarker; diagnosis; miRNA; non-small-cell lung cancer

PMID:
26309587
PMCID:
PMC4538081

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center